Prototyping Adaptive Online Learning Courses

This article describes the process of prototyping adaptive online learning using the authoring tool for developers, which is based on ontologies. The article also gives a brief overview of contemporary situation and describes modern trends of evolution e-learning courses and present standards in this area. It also describes architecture of system VITA II

Plasticity of Adipose Tissue-Derived Stem Cells and Regulation of Angiogenesis

Adipose tissue is recognized as an important organ with metabolic, regulatory, and plastic roles. Adipose tissue-derived stem cells (ASCs) with self-renewal properties localize in the stromal vascular fraction (SVF) being present in a vascular niche, thereby, contributing to local regulation of angiogenesis and vessel remodeling. In the past decades, ASCs have attracted much attention from biologists and bioengineers, particularly, because of their multilineage differentiation potential, strong proliferation, and migration abilities in vitro and high resistance to oxidative stress and senescence. Current data suggest that the SVF serves as an important source of endothelial progenitors, endothelial cells, and pericytes, thereby, contributing to vessel remodeling and growth. In addition, ASCs demonstrate intriguing metabolic and interlineage plasticity, which makes them good candidates for creating regenerative therapeutic protocols, in vitro tissue models and microphysiological systems, and tissue-on-chip devices for diagnostic and regeneration-supporting purposes. This review covers recent achievements in understanding the metabolic activity within the SVF niches (lactate and NAD+ metabolism), which is critical for maintaining the pool of ASCs, and discloses their pro-angiogenic potential, particularly, in the complex therapy of cardiovascular and cerebrovascular diseases

Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice

金沢大学医薬保健研究域医学系Oxytocin sets the stage for childbirth by initiating uterine contractions, lactation and maternal bonding behaviours. Mice lacking secreted oxcytocin (Oxt -/-, Cd38 -/-) or its receptor (Oxtr -/-) fail to nurture. Normal maternal behaviour is restored by peripheral oxcytocin replacement in Oxt -/- and Cd38 -/-, but not Oxtr -/- mice, implying that circulating oxcytocin crosses the blood-brain barrier. Exogenous oxcytocin also has behavioural effects in humans. However, circulating polypeptides are typically excluded from the brain. We show that oxcytocin is transported into the brain by receptor for advanced glycation end-products (RAGE) on brain capillary endothelial cells. The increases in oxcytocin in the brain which follow exogenous administration are lost in Ager -/- male mice lacking RAGE, and behaviours characteristic to abnormalities in oxcytocin signalling are recapitulated in Ager -/- mice, including deficits in maternal bonding and hyperactivity. Our findings show that RAGE-mediated transport is critical to the behavioural actions of oxcytocin associated with parenting and social bonding.3082047

Teaching Russian classics in secondary school under Stalin (1936-1941)

This thesis contributes to existing discussions of Soviet subjectivity by considering how the efforts of the Party leadership and state agencies to shape personal and collective identities were mediated by the teaching of Russian classics to teenagers. It concentrates in particular on the history of literature course provided by Soviet schools for the upper years. The study addresses the following questions: (1) How was literary expression employed to instigate childrenâs emotions and create interpretive habits as a way of inculcating a Soviet worldview? (2) What immediate effects did the methods have on teenagers? (3) What were the long-term effects of this type of indoctrination? Answering these questions required close reading of material produced by official authorities, such as methodological programmes, teachers' aids, professional journals, and textbooks for class instruction, and also of material produced by those at the receiving end of Stalinist literary instruction, including both sources contemporary to the period under scrutiny (i.e. diaries written between 1936 â 1941), and later autobiographical material (memoirs, oral history). I argue that for many teenagers growing up during this period, indoctrination in the classroom blurred the boundary between reality and fiction, and provided a moral compass to navigate their social environment, to judge others as well as themselves along prescribed lines, and model their lives on the precepts and slogans of the characters and authors they encountered, particularly the 19th-century radical democrats. Retrospective accounts â interviews, memoirs, and written responses to questions â expose the durability of the moral and ethical lessons derived from Russian classics and reveal the enduring Soviet emotional complex formed by this literary instruction. Investigating the impacts of the study of Russian classics on Soviet recipients, particularly from elite groups such as the city intelligentsia, my discussion highlights the political traction of the literary in, for instance, forming feelings of group belonging and strong emotional responses to differing views. I conclude with a discussion of the relation of this to long-term political effects, including the re-appraisal, in the twenty-first century, of Stalin-era teaching methodology as an effective way of instilling patriotic sentiments in students, and the legacy of Soviet perceptions and practices in the expression of personal and collective identities in the post-Soviet period.</p

Stylistic stratagems in The Cloud of Unknowing

Malinovskaya Olga. Stylistic stratagems in The Cloud of Unknowing. In: Bulletin des anglicistes médiévistes, N°84, Printemps 2014. pp. 25-51

SANITARY REFORMS IN EAST ASIA IN THE SECOND HALF OF THE 19TH AND THE FIRST HALF OF THE 20TH CENTURIES (HONG KONG’ AND SHANGHAI’ CASES)

The aim of the study is to analyze the history of sanitary reforms in East Asia on the territory of two European enclaves (Hong Kong and Shanghai), which became important centers of transit of Western public health theories and practices to China in the second half of XIX - first half of XX centuries. The relevance of the research is conditioned by the necessity of understanding the historical experience of social processes management in complex epidemiological situations and development of Russian society response to new big challenges, connected with epidemic spreading. The novelty of the study consists in clarifying the existing scientific picture of the formation of modern public health management institutions in East Asia during the period from the beginning of European expansion into China to the Japanese invasion. The study was conducted in 2022 using primary sources from digital libraries in London (Wellcome Collection), Hong Kong (Digital Repository of Hong Kong University), and Shanghai (Virtual Shanghai), as well as works by Western and Chinese historians on public health and sanitation in Asia. During the study methods of historical knowledge were used: problem-chronological, comparative-historical, historical-typological. Methodology of social history of public health became the theoretical base of research. The conclusions of the study are as follows. Sanitary reforms began in those parts of East Asia where European influence was strong. At the forefront of the reforms were the British colony of Hong Kong and the international settlements in Shanghai, where Europeans had to adapt to the difficult conditions of climate, the burden of infectious diseases, and constant overcrowding. Rationalizing the management of urban space, they did not try to offer their way of life to the Chinese population, seeing them as culturally backward and unable to assimilate such civilizational achievements as sewage and running water, but under the pressure of economic and epidemiological 6 needs this step was taken. As a result, by the end of the 1930s, Hong Kong and Shanghai had become prosperous cities with relatively good sanitary and epidemiological condition

Photodegradation of bisphenol A in the presence of superfine microfiber polypropylene

The effect of UV radiation on the efficiency phototransformation BPA in water in the presence of polypropylene superfine microfibers. The absorption and fluorescence spectra of the investigated substance with three types of PPM of various properties were obtained. After excitation with an excilamp, the main photoproduct BPA fluoresces in the region of 405÷410 nm. With an increase in the irradiation time from 0 to 10 minutes, an increase in the fluorescence intensity of this BPA photoproduct was recorded. This indicates that in the course of irradiation, effective photodegradation of the initial toxicant occurs and a photoproduct is formed. In the course of irradiation, the degradation of the resulting photoproducts occurs, which is associated with their adsorption on the surface of the PPM